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Title Analysis of aggregates and particles in protein pharmaceuticals [electronic resource] / edited by Hanns-Christian Mahler, Wim Jiskoot.
Publication Info. Hoboken, N.J. : John Wiley & Sons, Inc., 2012.
Location Call No. Status Notes
 Libraries Electronic Books  ELECTRONIC BOOK-ebrary    AVAIL. ONLINE
Description xvi, 443 p., [12] p. of plates : ill. (some col.)
Bibliography Includes bibliographical references.
Contents The critical need for robust assays for quantitation and characterization of aggregates of therapeutic proteins -- Separation based analytical methods for measuring protein aggregation -- Laser light scattering-based techniques used for the characterization of protein therapeutics -- Online detection methods and emerging techniques for soluble aggregates in protein pharmaceuticals -- Analytical methods to measure sub-visible particulates -- Detection of visible particles in parenteral products -- Characterization of aggregates and particles using emerging techniques -- Ultraviolet absorption spectroscopy -- Fluorescence spectroscopy to characterize protein aggregates and particles -- Infrared spectroscopy to characterize protein aggregates -- Raman microscopy for characterization of particles -- Microscopic methods for particle characterization in protein pharmaceuticals -- Comparison of methods for soluble aggregate detection and size characterization -- Protein purification and its relation to protein aggregation and particles -- Formulation development and its relation to protein aggregation and particles.
Reproduction Electronic reproduction. Palo Alto, Calif. : ebrary, 2012. Available via World Wide Web. Access may be limited to ebrary affiliated libraries.
Subject Pharmaceutical chemistry.
Protein drugs -- Analysis.
Added Author Mahler, Hanns-Christian.
Jiskoot, Wim.
ebrary, Inc.
ISBN 9780470497180 (cloth)
9781118150542 (e-book)
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