| Description |
1 online resource. |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Note |
Print version cataloged as a monographic set by Library of Congress. |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Front Cover; Strategies and Tactics in Organic Synthesis; Copyright; Dedication; Contents; Contributors; Preface; Chapter 1: Substrate-Directed Heck-Matsuda Arylations: From Curiosity to a Valuable Synthetic Tool; 1. Introduction and Overview; 2. Substrate-Directed Heck-Matsuda Reaction; 2.1. Some Preliminary Results; 3. Development and Synthetic Applications of the Substrate-Directed Heck-Matsuda Reaction; 3.1. Stereoselective Arylation of Allylic Esters; 3.2. Stereoselective Arylation of N-Protected Allylic Amine Derivatives; 3.3. Stereoselective Arylation of Cyclopentene Scaffolds |
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4. Conclusion Acknowledgments; References; Chapter 2: (-)-Berkelic Acid: Lessons Learned From Our Investigations on a Scalable Total Synthesis; 1. Introduction: Isolation and Interest on Berkelic Acid; 2. Structural Assignation and Previous Total Syntheses of (-)-Berkelic Acid; 3. Our Approach to Berkelic Acid from Research on New Methodology: Model Studies; 4. Retrosynthetic Analysis; 5. Our Synthesis of (-)-Berkelic Acid; 6. Conclusions; Acknowledgments; References; Chapter 3: The Mysterious Case of the Kingianins; 1. Introduction-What's Going on Here? |
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1.1. The Structure of Kingianin A-Diels-Alder Origins?1.2. The Kingianin Series-Structures and Biological Activities; 2. Analysis of the Problem-Regio- and Stereochemical Issues; 3. Preliminaries: Tests of the RCDA Approach with Model Compounds; 3.1. Preparation of a Simple Model System; 3.2. Feasibility of the Key RCDA Step; 4. Selecting a Strategy for the Total Synthesis of Kingianin A; 5. Getting Started: Synthesis of a Pre-Kingianin A Equivalent; 6. Pursuit of the Intramolecular RCDA Approach; 6.1. Selection of an RCDA Substrate; 6.2. Observations; 6.3. A Digression |
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7. Synthesis of Kingianin A8. ̀̀Go Fish́ ́ -Pursuit of the Intermolecular RCDA Approach; 9. Formal Synthesis of Kingianin A and Synthesis of Kingianins D, F, H, and J; 10. NCI 60 Test Results for Kingianins A (NSC#D-768505/1) and H (NSC#D-768506/1); 11. Reconsidering the Biosynthesis; 12. Conclusions; Acknowledgments; References; Chapter 4: Total Synthesis of Chinensiolide B: An Exercise in Functional Group Selectivity with the Help of a Fortuitous Side product and a good nose; 1. Introduction; 1.1. Chinensiolide and Other α-Methylene γ-Lactones in Nature |
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1.2. Traditional Methods for the Synthesis of α-Methylene γ-Lactones1.3. Use of 2-Alkoxycarbonyl Allylboronates to Access α-Methylene γ-Lactones; 2. Model Studies and Retrosynthetic Analysis; 2.1. Retrosynthetic Analysis; 2.2. Model Studies; 3. Design and Synthesis of the Key Allylboronate; 3.1. Selection of the Protecting Group; 3.2. Synthesis of Disubstituted Allylboronate 7; 4. Synthesis of the Cyclopentyl Aldehyde Substrate; 4.1. Literature Precedent; 4.2. Preparation of Aldehyde 6; 5. Critical Moment-The Key Aldehyde Allylboration Step |
| Note |
5.1. History and Theory of the Carbonyl Allylboration Reaction |
| Reproduction |
Electronic reproduction. Ipswich, MA Available via World Wide Web. |
| Note |
Description based on online resource; title from digital title page (viewed on October 8, 2014). |
| Subject |
Organic compounds -- Synthesis.
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| Added Author |
Harmata, Michael, 1959- editor.
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EBSCOhost
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| Related To |
Print version: Harmata, Michael Strategies and Tactics in Organic Synthesis Burlington : Elsevier Science,c2014 9780124171855 |
| ISBN |
9780124171916 electronic bk. |
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0124171915 electronic bk. |
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9780124171855 |
| OCLC # |
co8844924 |
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