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Author Carpenter, David O.
Title Effects of persistent and bioactive organic pollutants on human health [electronic resource] / edited by David O. Carpenter.
Publication Info. Hoboken, New Jersey : Wiley, c2013.
Edition First edition.
Location Call No. Status Notes
 Libraries Electronic Books  ELECTRONIC BOOKS-DDA    AVAIL. ONLINE
Description 1 online resource.
Bibliography Includes bibliographical references and index.
Reproduction Electronic reproduction. Perth, W.A. Available via World Wide Web.
Note Description based on online resource; title from PDF title page (Wiley, viewed August 15, 2013)
Edition statement from running title area.
Contents Cover; Title page; Copyright page; Contents; Contributors; CHAPTER 1: Introduction: Why Should We Care about Organic Chemicals and Human Health?; References; CHAPTER 2: Sources of Human Exposure; Introduction; Human Exposure Pathways; Direct or Nondietary; Dietary; Chemicals of Concern; POPs; Pesticides; Benzene; Perfluoroalkyl Substances (PFASs); Conclusions and Recommendations; References; CHAPTER 3: The Burden of Cancer from Organic Chemicals; Introduction; The Global Burden of Cancer; Childhood Cancers; Exposure to Organic Chemicals: Contributions to the Global Burden of Cancer
OccupationalOutdoor Air Pollution; Indoor Air Pollution; Water Pollution; Consumer Products; Food Contaminants; Pesticides; 2,4-Dichlorophenoxyacetic Acid (2,4-D): Health Impacts of a Widely Used Organic Chemical Herbicide; Linking Chemicals to Specific Cancer Sites; Examples of Individual Organic Chemicals; Sources of Exposure Information; Estimating the Percentage of Cancers Attributable to Occupational and Environmental Exposures: Methodological and Conceptual Difficulties; Efforts to Estimate Attributable Fractions; Causes: Genes or Environment?; Conclusion: Opportunities for Prevention
Bibliography ReferencesCHAPTER 4: Carcinogenicity and Mechanisms of Persistent Organic Pollutants; Introduction; Many POPs Are Complete Carcinogens in Animal Studies; Aspects of Cancer Induction; Carcinogenesis Is a Multistep Process; Compounds May Require Metabolic Bioactivation to Reactive Intermediates and/or By-Products to Act as Carcinogens: Example Lower-Chlorinated Biphenyls; Direct versus Indirect Action; Cancer-Initiating Activity of POPs; Cancer Initiation Is Based on Genotoxic Events; Initiating and Genotoxic Activity of POPs In Vitro and In Vivo; Genotoxicity of Individual Pesticides
Contents Tumor-Promoting Activities of Environmental PollutantsPromoting Activity of Individual POPs; Mechanisms of Tumor Promotion by Environmental Pollutants; Progression in Carcinogenesis; Summary and Conclusion; Acknowledgments; References; CHAPTER 5: Diabetes and the Metabolic Syndrome; Introduction; Why Is There an Epidemic of T2D?; Human Evidence Linking POPs and T2D; Earlier Evidence; Recent Evidence: Cross-Sectional Studies; Recent Evidence: Prospective Studies; Human Evidence Linking POPs and Metabolic Syndrome; Mismatch of Time Trend: Issues Related to Inverted U-Shaped Associations
Polybrominated Biphenyl Ethers (PBDEs) and T2DThrifty Gene Hypothesis and POPs; POPs and Glycemic Control among Diabetic Patients; Dietary Interventions in T2D; Summary; References; CHAPTER 6: Mechanistic Basis for Elevation in Risk of Diabetes Caused by Persistent Organic Pollutants; Introduction; Diabetes; POPs: Novel Diabetogenic Factors; POPs and Diabetes: Mechanistic Basis; AhR; CAR and SXR; Challenges and Perspectives; References; CHAPTER 7: Cardiovascular Disease and Hypertension; Introduction; Animal Studies and Laboratory Evidence
Note Standardized Mortality Ratios (SMRs) for Heart Disease
Subject Bioactive compounds -- Toxicology.
Organic compounds -- Toxicology.
Persistent pollutants -- Health aspects.
Organic Chemicals -- adverse effects.
Organic compounds -- Toxicology.
Added Author Ebooks Corporation
Related To Print version: Carpenter, David O. Effects of persistent and bioactive organic pollutants on human health. Hoboken, New Jersey : John Wiley & Sons, Inc., 2013 9781118159262 (DLC) 2013004573
ISBN 9781118679654 (electronic bk.)
1118679652 (electronic bk.)
9781118679494 (electronic bk.)
1118679490 (electronic bk.)
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