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Title Primer on the metabolic bone diseases and disorders of mineral metabolism [electronic resource] / editor-in-chief, Clifford J. Rosen ; senior associate editors, Roger Bouillon, Juliet E. Compston, Vicki Rosen ; associate editors, Douglas C. Bauer ... [et al.].
Publication Info. Ames, Iowa : Wiley-Blackwell, 2013.
Edition 8th ed.
Location Call No. Status Notes
 Libraries Electronic Books  ELECTRONIC BOOKS-DDA    AVAIL. ONLINE
Description 1 online resource.
Bibliography Includes bibliographical references and index.
Contents Cover; Title page; Copyright page; Contents; Contributors; Primer Corporate Sponsors; Preface to the Eighth Edition of the Primer; About ASBMR; President's Preface; About the Companion Website; Section I: Molecular Cellular and Genetic Determinants of Bone Structure and Formation; 1: Skeletal Morphogenesis and Embryonic Development; Early Skeletal Patterning; Craniofacial patterning; Axial patterning; Limb patterning; Embryonic Cartilage and Bone Formation; Chondrocyte Proliferation and Differentiation in The Developing Cartilage; Regulation of Chondrocyte Survival; Conclusions; References.
2: Signal Transduction Cascades Controlling Osteoblast DifferentiationIntroduction; Runx2 and Osterix Transcription Factors; BMP Signaling; TGF-ß Signaling; WNT Signaling; Hedgehog Signaling; PTH Signaling; IGF-1 Signaling; FGF Signaling; Notch Signaling; Concluding Remarks; Acknowledgments; References; 3: Osteoclast Biology and Bone Resorption; Cell Biology of The Osteoclast; Integrin Signaling; Small GTPases; Factors Regulating Osteoclast Formation And/Or Function; Proteins; Small molecules; Cell-Cell Interactions in Bone Marrow; Intracellular Signaling Pathways; Human Genetics; References.
4: OsteocytesIntroduction; Osteocyte Ontogeny; Osteocytes as Orchestrators of Bone (Re)Modeling; Osteocyte Cell Death and Apoptosis; Osteocyte Modification of Their Microenvironment; Mechanosensation and Transduction; Role of Gap Junctions and Hemichannels in Osteocyte Communication; The Potential Role of Osteocytes in Bone Disease; Acknowledgment; References; 5: Connective Tissue Pathways That Regulate Growth Factors; Introduction; The Fibrillinopathies; Fibrillin Microfibrils; Regulation of Growth Factors by Fibrillin Microfibrils; Molecular Mechanisms Orchestrated on a Microfibril Scaffold.
Nanocomputed TomographyImaging Considerations; Voxel size and image resolution; Segmentation; Skeletal site and volume of interest; Calibration; Other considerations; Conclusions; References; 8: Animal Models: Genetic Manipulation; Introduction; Overexpression of Target Genes; Chondrocytes; Osteoblasts; Tendon and ligament; Osteoclasts; Advantages and disadvantages of overexpression approaches; Gene Targeting; Advantages and disadvantages of gene targeting; Tissue-Specific and Inducible Knockout and Overexpression; Uncondensed mesenchyme, mesenchymal condensations, and neural crest; Cartilage; Osteoblasts.
Reproduction Electronic reproduction. Perth, W.A. Available via World Wide Web.
Note Description based on online resource; title from digital title page (viewed on Sept. 10, 2013).
Subject Bones -- Metabolism -- Disorders.
Mineral metabolism -- Disorders.
Bones -- Diseases.
Bone Diseases, Metabolic.
Bone and Bones -- metabolism.
Minerals -- metabolism.
Added Author Rosen, Clifford J.
Bouillon, R.
Compston, Juliet E.
Rosen, Vicki.
Ebooks Corporation
Related To Print version: Primer on the metabolic bone diseases and disorders of mineral metabolism. 8th ed. Ames, Iowa : Wiley-Blackwell, 2013 9781118453889 (DLC) 2013002831
ISBN 9781118453902 (electronic bk.)
1118453905 (electronic bk.)
9781118453926 (electronic bk.)
1118453921 (electronic bk.)
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