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Title Non-peptide inhibitors of proprotein convertase subtilisin kexins (PCSKs) [electronic resource] : an overall review of existing and new data / Utpal Chandra ... [et al.].
Publication Info. San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, c2012.
Location Call No. Status Notes
 Libraries Electronic Books  ELECTRONIC BOOKS-DDA    AVAIL. ONLINE
Description 1 online resource.
Series Colloquium digital library of life sciences.
Colloquium series on protein activation and cancer ; # 3.
Note Part of: Colloquium digital library of life sciences.
Title from PDF t.p. (viewed Oct. 19, 2012).
Series from website.
Bibliography Includes bibliographical references (p. 53-64).
Contents 1. Introduction -- 2. Historical perspectives -- 3. Class of PCSK inhibitors -- 3.1 Macromolecules -- 3.2 Small molecules -- 4. Comparative analyses of peptide and non-peptide inhibitors -- 5. Class of non-peptide inhibitors of PCSKs -- 5.1 Carbocyclic compounds -- 5.2 Heterocyclic compounds -- 5.3 Aromatic compounds -- 5.4 C2-symmetrical aromatic azo compounds -- 6. Comparison of activities of non-peptide inhibitors of PCSK enzymes -- 7. Blockade of proprotein processing by non-peptide PCSK inhibitors in cellular models -- 8. Animal study with non-peptide PCSK inhibitors -- 9. Future perspectives of non-peptide PCSK inhibitors and concluding remarks -- 10. Acknowledgments -- References -- Titles of related interest.
Indexed In: Google scholar
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Reproduction Electronic reproduction. Perth, W.A. Available via World Wide Web.
Subject Protein precursors.
Enzyme inhibitors -- Therapeutic use.
Proprotein Convertases.
Enzyme Inhibitors -- therapeutic use.
proprotein convertase subtilisin kexins (PCSKs)
PCSK inhibitors
inhibition constant
inhibitor design
therapeutic agents
protein processing
peptide bond cleavage
protease assay
fluorogenic substrates
intramolecularly quenched fluorogenic peptides
Added Author Chandra, Utpal.
Ebooks Corporation
Related To Print version: 9781615044740
ISBN 9781615044757 (electronic bk.)
1615044752 (electronic bk.)
9781615044740 (pbk.)
Standard No. 10.4199/C00066ED1V01Y201209PAC003 doi
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