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Title Non-peptide inhibitors of proprotein convertase subtilisin kexins (PCSKs) [electronic resource] : an overall review of existing and new data / Utpal Chandra ... [et al.].
Publication Info. San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, c2012.
Location Call No. Status Notes
 Libraries Electronic Books  ELECTRONIC BOOKS-DDA    AVAIL. ONLINE
Description 1 online resource.
Series Colloquium digital library of life sciences.
Colloquium series on protein activation and cancer ; # 3.
Note Part of: Colloquium digital library of life sciences.
Title from PDF t.p. (viewed Oct. 19, 2012).
Series from website.
Bibliography Includes bibliographical references (p. 53-64).
Contents 1. Introduction -- 2. Historical perspectives -- 3. Class of PCSK inhibitors -- 3.1 Macromolecules -- 3.2 Small molecules -- 4. Comparative analyses of peptide and non-peptide inhibitors -- 5. Class of non-peptide inhibitors of PCSKs -- 5.1 Carbocyclic compounds -- 5.2 Heterocyclic compounds -- 5.3 Aromatic compounds -- 5.4 C2-symmetrical aromatic azo compounds -- 6. Comparison of activities of non-peptide inhibitors of PCSK enzymes -- 7. Blockade of proprotein processing by non-peptide PCSK inhibitors in cellular models -- 8. Animal study with non-peptide PCSK inhibitors -- 9. Future perspectives of non-peptide PCSK inhibitors and concluding remarks -- 10. Acknowledgments -- References -- Titles of related interest.
Indexed In: Google scholar
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Reproduction Electronic reproduction. Perth, W.A. Available via World Wide Web.
Subject Protein precursors.
Enzyme inhibitors -- Therapeutic use.
Proprotein Convertases.
Enzyme Inhibitors -- therapeutic use.
proprotein convertase subtilisin kexins (PCSKs)
PCSK inhibitors
non-peptides
inhibition constant
inhibitor design
therapeutic agents
protein processing
peptide bond cleavage
protease assay
fluorogenic substrates
intramolecularly quenched fluorogenic peptides
Added Author Chandra, Utpal.
Ebooks Corporation
Related To Print version: 9781615044740
ISBN 9781615044757 (electronic bk.)
1615044752 (electronic bk.)
9781615044740 (pbk.)
Standard No. 10.4199/C00066ED1V01Y201209PAC003 doi
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