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Author Husain, Zahabiya
Title The prdm gene apoptix antagonizes programmed cell death in tribolium [electronic resource] / by Zahabiya Husain.
Publication Info. 2012.
Location Call No. Status Notes
 Libraries Electronic Books  Electronic Resource - WSU ETD    AVAIL. ONLINE
Note Thesis supervisor: Dr. Markus Friedrich
Thesis Thesis (M.S.)--Wayne State University, 2012.
Summary Previous studies in holometabolous insects have shown that programmed and cell proliferation play important roles in insect metamorphosis. To elucidate the function of the newly identified Tribolium Prdm gene Apoptix (Apox) I performed a detailed analysis of Apox knockdown effects in the embryo, the pupa and the adult eye. My results revealed that Apox is required for the survival of retinal tissue after onset of differentiation and also generally in tissues which experience high amounts of proliferation and differentiation during pupal development. Further, combinatorial knockdown of Apox and initiator caspases produced evidence that Apox specifically protects from programmed cell death in Tribolium development. My results characterize a novel regulator of programmed cell death, which is highly conserved in arthropods but was lost during dipteran evolution.
System Details Mode of access: World Wide Web.
System requirements: Adobe Reader.
Added Author Dr. Markus Friedrich, advisor.
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